Publikationen

Wirthgen, Elisa; Quickert, Susann; Weitzel, Julia; Salewski, Birgit; Ballmann, Manfred (2025): Safety of biologics for the treatment of asthma in children and adolescents: a systematic review. In: European respiratory review : an official journal of the European Respiratory Society 34 (176). DOI: 10.1183/16000617.0269-2024.

Winkel, Paul P.; Bergmann-Ewert, Wendy; Reiner, Johannes; Huth, Astrid; Kleimeier, Dana; Casalegno Garduño, Rosaely; Wrobel, Ida M.; Domanska, Grazyna; Däbritz, Jan; Wirthgen, Elisa. (2025): Peripheral monocytes from Crohn's disease patients retain functional responsiveness to GM-CSF during active disease. In: Frontiers in immunology 16, S. 1663713. DOI: 10.3389/fimmu.2025.1663713.

Wirthgen, Elisa; Weber, Frank; Kubickova-Weber, Laura; Schiller, Benjamin; Schiller, Sarah; Radke, Michael; Däbritz, Jan (2024): Corrigendum: Identifying predictors of clinical outcomes using the projection-predictive feature selection-a proof of concept on the example of Crohn's disease. In: Frontiers in pediatrics 12, S. 1420531. DOI: 10.3389/fped.2024.1420531.

Schiller, B.; Wirthgen, E.; Weber, F.; Schiller, S.; Radke, M.; Claßen, M.; Däbritz, J. (2024): Fecal calprotectin and platelet count predict histologic disease activity in pediatric ulcerative colitis: results from a projection-predictive feature selection. In: European journal of pediatrics 183 (8), S. 3277–3288. DOI: 10.1007/s00431-024-05554-y.

Wichmann, Christopher; Wirthgen, Elisa; Nowosad, Carla R.; Däbritz, Jan (2024): B cell academy of the gut: an update on gut associated germinal centre B cell dynamics. In: Molecular and cellular pediatrics 11 (1), S. 7. DOI: 10.1186/s40348-024-00180-y.

Wirthgen, Elisa; Domanska, Grazyna (2024): Editorial: Polarization of cellular immune response in the context of inflammation and cancer. In: Frontiers in immunology 15, S. 1433808. DOI: 10.3389/fimmu.2024.1433808.

Manteuffel, Christian; Spitschak, Marion; Ludwig, Carolin; Wirthgen, Elisa (2023): New Perspectives In The Objective Evaluation Of Animal Welfare, With Focus On The Domestic Pig. In: Journal of applied animal welfare science : JAAWS 26 (4), S. 518–529. DOI: 10.1080/10888705.2021.1998774.

Klamt, Juliane; Laffolie, Jan de; Wirthgen, Elisa; Stricker, Sebastian; Däbritz, Jan (2023): Predicting complications in pediatric Crohn's disease patients followed in CEDATA-GPGE registry. In: Frontiers in pediatrics 11, S. 1043067. DOI: 10.3389/fped.2023.1043067.

Wirthgen, Elisa; Weber, Frank; Kubickova-Weber, Laura; Schiller, Benjamin; Schiller, Sarah; Radke, Michael; Däbritz, Jan (2023): Identifying predictors of clinical outcomes using the projection-predictive feature selection-a proof of concept on the example of Crohn's disease. In: Frontiers in pediatrics 11, S. 1170563. DOI: 10.3389/fped.2023.1170563.

Hornschuh, Melanie; Haas, Vivian; Winkel, Paul P.; Gökyildirim, Mira Y.; Mullins, Christina S.; Wrobel, Ida Maria et al. (2022): Negative Magnetic Sorting Preserves the Functionality of Ex Vivo Cultivated Non-Adherent Human Monocytes. In: Biology 11 (11). DOI: 10.3390/biology11111583.

Hinterseher, Julia; Günther, Juliane; Zlatina, Kristina; Isernhagen, Lisa; Viergutz, Torsten; Wirthgen, Elisa et al. (2022): Milk Polysialic Acid Levels Rapidly Decrease in Line with the N-Acetylneuraminic Acid Concentrations during Early Lactation in Dairy Cows. In: Biology 12 (1). DOI: 10.3390/biology12010005.

Wirthgen, Elisa; Hornschuh, Melanie; Wrobel, Ida Maria; Manteuffel, Christian; Däbritz, Jan (2021): Mimicking of Blood Flow Results in a Distinct Functional Phenotype in Human Non-Adherent Classical Monocytes. In: Biology 10 (8). DOI: 10.3390/biology10080748.

Hornschuh, M.; Wirthgen, E.; Wolfien, M.; Singh, K. P.; Wolkenhauer, O.; Däbritz, J. (2021): The role of epigenetic modifications for the pathogenesis of Crohn's disease. In: Clinical epigenetics 13 (1), S. 108. DOI: 10.1186/s13148-021-01089-3.

Riess, Christin; Schneider, Björn; Kehnscherper, Hanna; Gesche, Julia; Irmscher, Nina; Shokraie, Fatemeh et al. (2020): Activation of the Kynurenine Pathway in Human Malignancies Can Be Suppressed by the Cyclin-Dependent Kinase Inhibitor Dinaciclib. In: Frontiers in immunology 11, S. 55. DOI: 10.3389/fimmu.2020.00055.

Cornish, Jack S.; Wirthgen, Elisa; Däbritz, Jan (2020): Biomarkers Predictive of Response to Thiopurine Therapy in Inflammatory Bowel Disease. In: Frontiers in medicine 7, S. 8. DOI: 10.3389/fmed.2020.00008.

Günther, Juliane; Fallarino, Francesca; Fuchs, Dietmar; Wirthgen, Elisa (2020): Editorial: Immunomodulatory Roles of Tryptophan Metabolites in Inflammation and Cancer. In: Frontiers in immunology 11, S. 1497. DOI: 10.3389/fimmu.2020.01497.

Wirthgen, Elisa; Leonard, Anne K.; Scharf, Christian; Domanska, Grazyna (2020): The Immunomodulator 1-Methyltryptophan Drives Tryptophan Catabolism Toward the Kynurenic Acid Branch. In: Frontiers in immunology 11, S. 313. DOI: 10.3389/fimmu.2020.00313.

Günther, Juliane; Däbritz, Jan; Wirthgen, Elisa (2019): Limitations and Off-Target Effects of Tryptophan-Related IDO Inhibitors in Cancer Treatment. In: Frontiers in immunology 10, S. 1801. DOI: 10.3389/fimmu.2019.01801.

Brenmoehl, Julia; Ohde, Daniela; Wirthgen, Elisa; Hoeflich, Andreas (2018a): Cytokines in milk and the role of TGF-beta. In: Best practice & research. Clinical endocrinology & metabolism 32 (1), S. 47–56. DOI: 10.1016/j.beem.2018.01.006.

Brenmoehl, Julia; Walz, Christina; Spitschak, Marion; Wirthgen, Elisa; Walz, Michael; Langhammer, Martina et al. (2018b): Partial phenotype conversion and differential trait response to conditions of husbandry in mice. In: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 188 (3), S. 527–539. DOI: 10.1007/s00360-017-1138-x.

Wirthgen, Elisa; Goumon, Sébastien; Kunze, Martin; Walz, Christina; Spitschak, Marion; Tuchscherer, Armin et al. (2018a): Effects of Transport Duration and Environmental Conditions in Winter or Summer on the Concentrations of Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins in the Plasma of Market-Weight Pigs. In: Frontiers in endocrinology 9, S. 36. DOI: 10.3389/fendo.2018.00036.

Mense, Kirsten; Heidekorn-Dettmer, Julia; Wirthgen, Elisa; Brockelmann, Yette; Bortfeldt, Ralf; Peter, Sarah et al. (2018): Increased Concentrations of Insulin-Like Growth Factor Binding Protein (IGFBP)-2, IGFBP-3, and IGFBP-4 Are Associated With Fetal Mortality in Pregnant Cows. In: Frontiers in endocrinology 9, S. 310. DOI: 10.3389/fendo.2018.00310.

Nipkow, Mareen; Wirthgen, Elisa; Luft, Peter; Rebl, Alexander; Hoeflich, Andreas; Goldammer, Tom (2018): Characterization of igf1 and igf2 genes during maraena whitefish (Coregonus maraena) ontogeny and the effect of temperature on embryogenesis and igf expression. In: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 40, S. 32–43. DOI: 10.1016/j.ghir.2018.04.003.

Wirthgen, Elisa; Otten, Winfried; Tuchscherer, Margret; Tuchscherer, Armin; Domanska, Grazyna; Brenmoehl, Julia et al. (2018b): Effects of 1-Methyltryptophan on Immune Responses and the Kynurenine Pathway after Lipopolysaccharide Challenge in Pigs. In: International journal of molecular sciences 19 (10). DOI: 10.3390/ijms19103009.

Schindler, N.; Mayer, J.; Saenger, S.; Gimsa, U.; Walz, C.; Brenmoehl, J. et al. (2017): Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin-Weintraub sequence motif: Reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like behaviour. In: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 33, S. 1–8. DOI: 10.1016/j.ghir.2016.11.003.

Um, Caroline Y.; Fedirko, Veronika; Flanders, W. Dana; Höflich, Christine; Wirthgen, Elisa; Bostick, Roberd M. (2017): Circulating insulin-like growth factor-related biomarkers: Correlates and responses to calcium supplementation in colorectal adenoma patients. In: Molecular carcinogenesis 56 (9), S. 2127–2134. DOI: 10.1002/mc.22669.

Meyer, Zianka; Höflich, Christine; Wirthgen, Elisa; Olm, Sven; Hammon, Harald M.; Hoeflich, Andreas (2017): Analysis of the IGF-system in milk from farm animals - Occurrence, regulation, and biomarker potential. In: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 35, S. 1–7. DOI: 10.1016/j.ghir.2017.05.004.

Wirthgen, Elisa; Kunze, Martin; Goumon, Sébastien; Walz, Christina; Höflich, Christine; Spitschak, Marion et al. (2017a): Interference of stress with the somatotropic axis in pigs - lights on new biomarkers. In: Scientific reports 7 (1), S. 12055. DOI: 10.1038/s41598-017-11521-5.

Wirthgen, Elisa; Hoeflich, Andreas; Rebl, Alexander; Günther, Juliane (2017b): Kynurenic Acid: The Janus-Faced Role of an Immunomodulatory Tryptophan Metabolite and Its Link to Pathological Conditions. In: Frontiers in immunology 8, S. 1957. DOI: 10.3389/fimmu.2017.01957.

Wirthgen, Elisa; Kanitz, Ellen; Tuchscherer, Margret; Tuchscherer, Armin; Domanska, Grazyna; Weitschies, Werner et al. (2016a): Pharmacokinetics of 1-methyl-L-tryptophan after single and repeated subcutaneous application in a porcine model. In: Experimental animals 65 (2), S. 147–155. DOI: 10.1538/expanim.15-0096.

Wirthgen, Elisa; Höflich, Christine; Spitschak, Marion; Helmer, Carina; Brand, Bodo; Langbein, Jan et al. (2016b): Quantitative Western ligand blotting reveals common patterns and differential features of IGFBP-fingerprints in domestic ruminant breeds and species. In: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 26, S. 42–49. DOI: 10.1016/j.ghir.2015.11.001.

Ohde, Daniela; Brenmoehl, Julia; Walz, Christina; Tuchscherer, Armin; Wirthgen, Elisa; Hoeflich, Andreas (2016): Comparative analysis of hepatic miRNA levels in male marathon mice reveals a link between obesity and endurance exercise capacities. In: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 186 (8), S. 1067–1078. DOI: 10.1007/s00360-016-1006-0.

Oster, M.; Nuchchanart, W.; Trakooljul, N.; Muráni, E.; Zeyner, A.; Wirthgen, E. et al. (2016): Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight. In: European journal of nutrition 55 (4), S. 1717–1727. DOI: 10.1007/s00394-015-0990-2.

Schäff, Christine T.; Gruse, Jeannine; Maciej, Josefine; Mielenz, Manfred; Wirthgen, Elisa; Hoeflich, Andreas et al. (2016): Effects of Feeding Milk Replacer Ad Libitum or in Restricted Amounts for the First Five Weeks of Life on the Growth, Metabolic Adaptation, and Immune Status of Newborn Calves. In: PloS one 11 (12), e0168974. DOI: 10.1371/journal.pone.0168974.

Hoeflich, Andreas; Reyer, Anja; Ohde, Daniela; Schindler, Nancy; Brenmoehl, Julia; Spitschak, Marion et al. (2016): Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice. In: Aging cell 15 (1), S. 111–117. DOI: 10.1111/acel.12413.

Begemann, Matthias; Zirn, Birgit; Santen, Gijs; Wirthgen, Elisa; Soellner, Lukas; Büttel, Hans-Martin et al. (2015): Paternally Inherited IGF2 Mutation and Growth Restriction. In: The New England journal of medicine 373 (4), S. 349–356. DOI: 10.1056/NEJMoa1415227.

Kunze, Martin; Wirthgen, Elisa; Walz, Christina; Spitschak, Marion; Brenmoehl, Julia; Vanselow, Jens et al. (2015): Bioanalytical validation for simultaneous quantification of non-aromatic steroids in follicular fluid from cattle via ESI-LC-MS/MS. In: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 1007, S. 132–139. DOI: 10.1016/j.jchromb.2015.10.010.

Reyer, Anja; Schindler, Nancy; Ohde, Daniela; Walz, Christina; Kunze, Martin; Tuchscherer, Armin et al. (2015): The RGD sequence present in IGFBP-2 is required for reduced glucose clearance after oral glucose administration in female transgenic mice. In: American journal of physiology. Endocrinology and metabolism 309 (4), E409-17. DOI: 10.1152/ajpendo.00168.2015.

Wirthgen, Elisa; Hoeflich, Andreas (2015): Endotoxin-Induced Tryptophan Degradation along the Kynurenine Pathway: The Role of Indolamine 2,3-Dioxygenase and Aryl Hydrocarbon Receptor-Mediated Immunosuppressive Effects in Endotoxin Tolerance and Cancer and Its Implications for Immunoparalysis. In: Journal of amino acids 2015, S. 973548. DOI: 10.1155/2015/973548.

Meyerholz, Marie M.; Mense, Kirsten; Lietzau, Michael; Kassens, Ana; Linden, Matthias; Knaack, Hendrike et al. (2015): Serum IGFBP4 concentration decreased in dairy heifers towards day 18 of pregnancy. In: Journal of veterinary science 16 (4), S. 413–421. DOI: 10.4142/jvs.2015.16.4.413.

Laeger, T.; Wirthgen, E.; Piechotta, M.; Metzger, F.; Metges, C. C.; Kuhla, B.; Hoeflich, A. (2014): Effects of parturition and feed restriction on concentrations and distribution of the insulin-like growth factor-binding proteins in plasma and cerebrospinal fluid of dairy cows. In: Journal of dairy science 97 (5), S. 2876–2885. DOI: 10.3168/jds.2013-7671.

Bielohuby, Maximilian; Zarkesh-Esfahani, Sayyed Hamid; Manolopoulou, Jenny; Wirthgen, Elisa; Walpurgis, Katja; Toghiany Khorasgani, Mohaddeseh et al. (2014): Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth hormone agonists and antagonists in rabbits. In: Disease models & mechanisms 7 (11), S. 1263–1273. DOI: 10.1242/dmm.016519.

Wirthgen, Elisa; Tuchscherer, Margret; Otten, Winfried; Domanska, Grazyna; Wollenhaupt, Karin; Tuchscherer, Armin; Kanitz, Ellen (2014): Activation of indoleamine 2,3-dioxygenase by LPS in a porcine model. In: Innate immunity 20 (1), S. 30–39. DOI: 10.1177/1753425913481252.

Krieger, Frank; Elflein, Nicole; Saenger, Stefanie; Wirthgen, Elisa; Rak, Kristen; Frantz, Stefan et al. (2014): Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1. In: Brain : a journal of neurology 137 (Pt 5), S. 1374–1393. DOI: 10.1093/brain/awu059.

Hoeflich, Andreas; Wirthgen, Elisa; David, Robert; Classen, Carl Friedrich; Spitschak, Marion; Brenmoehl, Julia (2014): Control of IGFBP-2 Expression by Steroids and Peptide Hormones in Vertebrates. In: Frontiers in endocrinology 5, S. 43. DOI: 10.3389/fendo.2014.00043.